Craig Mayer, Nick WIlliams, Vojtech Huser
Lister Hill National Center for Biomedical Communications, National Library of Medicine, NIH, Bethesda, MD

See the full regCTG repository at https://github.com/lhncbc/CRI/tree/master/regCTG

To return to the list of conditions and view other reports go to https://lhncbc.github.io/CRI/regCTG/regCTG-condition_report_links.html

Study Counts

Type Study_count
Total_Studies 115
interventional 84
Observational 24
Registry 7

Studies over Time by Start Date

```

Interventional Trials

Intervention Type

intervention_type Study_Count
Device 23
Drug|placebo 12
Procedure 10
Drug 8
Biological 7
Other 5
Device|Other 4
Behavioral 3
Biological|placebo 3
Behavioral|Device 1
Behavioral|Other 1
Biological|Drug 1
Biological|Other 1
Device|Procedure 1
Diagnostic Test|Drug|placebo 1
Drug|Genetic|Procedure 1
Drug|Other|placebo 1
Radiation 1

Count of Studies by Intervention (normalized and mapped)

Interventions over Time

Yearly studies for each intervention by start date

Studies by Country

Country Study_Count
United States 33
Germany 5
Netherlands 5
NA 4
United Kingdom 4
Brazil 3
China 2
Germany|Netherlands 2
Israel 2
United States|Canada 2
Australia|Austria|Germany|Ireland 1
Australia|Austria|Germany|Ireland|New Zealand|United Kingdom 1
Australia|Brazil|Germany 1
Australia|Canada|Czech Republic|Denmark|Estonia|Finland|Germany|Ireland|Poland|Romania|Sweden 1
Austria|France|Germany|Israel 1
Austria|France|Germany|Italy|Netherlands|United Kingdom 1
Austria|Germany|Netherlands 1
Belgium|France|Germany|Netherlands|Sweden|United Kingdom 1
Canada|Denmark|Germany|Ireland|Netherlands|Sweden|United Kingdom 1
Denmark|Sweden|United Kingdom 1
Egypt 1
France 1
France|Germany|Netherlands 1
Italy 1
Japan| 1
Korea, Republic of 1
Spain 1
United States|Argentina|Australia|Brazil|Canada|Denmark|Estonia|France|Germany|New Zealand|Poland|Romania|Russian Federation|Spain|Sweden 1
United States|Australia|Canada|Czech Republic|Denmark|Estonia|Finland|Germany|Ireland|Poland|Romania|Russian Federation|Sweden 1
United States|Australia|Canada|Denmark|Estonia|New Zealand|Poland|Sweden 1
United States|Brazil|Netherlands|United Kingdom 1
United States|Bulgaria|Czech Republic|Hungary|Iceland|Israel|Italy|Latvia|Poland|South Africa|Ukraine|United Kingdom 1

Sites per Study

Site_count Study_Count
1 41
2 7
3 3
4 1
5 6
6 4
8 4
10 1
11 1
12 2
17 2
19 1
21 1
22 1
23 1
28 3
34 2
48 1
60 1
64 1

Phase

Phase Study_Count
N/A 32
Phase 2 18
Phase 4 9
Phase 1 8
Phase 3 8
Phase 1/Phase 2 5
Phase 2/Phase 3 4

Number of Arms

Number_of_Arms Count_of_Studies
1 29
2 35
3 8
4 1
NA 11

Enrollment Metrics by Phase

Measure N.A Phase.1 Phase.1.Phase.2 Phase.2 Phase.2.Phase.3 Phase.3 Phase.4
Min. 4.0000 6.00 8.0 10.0 10.0 32.0000 22.0000
1st Qu. 18.5000 9.00 25.0 16.5 17.5 82.5000 80.0000
Median 36.0000 13.00 36.0 27.0 40.0 250.0000 120.0000
Mean 163.5484 20.50 36.8 67.2 64.5 214.1429 126.2222
3rd Qu. 105.0000 29.75 55.0 61.0 87.0 304.5000 180.0000
Max. 3000.0000 47.00 60.0 491.0 168.0 443.0000 235.0000

Trial Group Type

group_type Group_Count
Experimental 73
Active Comparator 23
Placebo Comparator 18
NA 11
No Intervention 6
Other 5
Sham Comparator 2

Intervention Model

intervention_model Study_Count
Single Group Assignment 38
Parallel Assignment 36
Crossover Assignment 5
NA 5

Primary Purpose

primary_purpose Study_Count
Treatment 71
Basic Science 5
Diagnostic 4
Other 1
Prevention 1
Supportive Care 1
NA 1

Observational Studies

Studies by Country

Country Study_Count
United States 11
Belgium 3
United Kingdom 3
Germany 2
China 1
France 1
Israel 1
Italy 1
United States|Belgium|Canada|Denmark|Finland|Germany|Japan|Korea, Republic of|Poland|Spain|Sweden|United Kingdom 1

Sites per Study

Site_count Study_Count
1 18
2 3
5 1
21 1
51 1

Enrollment Metrics

Measure Observational
Min 10.0000
1st Qu 33.7500
Median 108.5000
Mean 585.4167
3rd Qu 232.0000
Max 10500.0000

Observation Model

observational_model Study_Count
Cohort 12
Case-Control 4
Case-Only 3
NA 2
Case-Crossover 1
Case Control 1
Other 1

Time Perspective

time_perspective Study_Count
Prospective 17
Cross-Sectional 5
Retrospective 1
NA 1

Registries

Studies by Country

Country Study_Count
United States 4
Austria|Germany|Switzerland 1
Germany|Switzerland|United Kingdom 1
Korea, Republic of 1

Sites per Study

Site_count Study_Count
1 3
2 2
3 1
21 1

Enrollment Metrics

Measure Registries
Min 2.00
1st Qu 60.00
Median 150.00
Mean 11224.57
3rd Qu 1650.00
Max 75000.00

Registry Model

observational_model Study_Count
Cohort 4
Case-Only 2
Other 1

Time Perspective

time_perspective Study_Count
Prospective 3
Cross-Sectional 2
Other 2

Follow-up

target_duration Study_Count
1 Year 1
15 Years 1
2 Months 1
2 Years 1
3 Months 1
3 Years 1
5 Years 1

Overview of Studies

Interventional Trials

#If less then 500 trials

nct_id brief_title link overall_status source primary_completion_date
NCT03382106 Smoking Cessation and Functional CT Assessment https://ClinicalTrials.gov/show/NCT03382106 Recruiting University of Iowa 2023-02-28
NCT03360396 Study of PneumRx Endobronchial Coil System in Treatment of Subjects With Severe Emphysema https://ClinicalTrials.gov/show/NCT03360396 Active, not recruiting PneumRx, Inc. 2020-04-30
NCT03244059 Belimumab Treatment of Emphysema Patients With Anti-GRP78 Autoantibodies https://ClinicalTrials.gov/show/NCT03244059 Recruiting University of Alabama at Birmingham 2020-07-31
NCT03114020 Efficacy/Safety of HA Inhalation Solution for Hereditary Emphysema in Patients With Alpha-1 Antitrypsin Deficiency https://ClinicalTrials.gov/show/NCT03114020 Completed Turino, Gerard, M.D. 2019-11-12
NCT03010449 LVR in Severe Emphysema Using Bronchoscopic Autologous Blood Instillation in Combination With Intra-bronchial Valves https://ClinicalTrials.gov/show/NCT03010449 Recruiting Royal Brompton & Harefield NHS Foundation Trust 2020-02-29
NCT03008915 Targeting Pulmonary Perfusion in Alpha-1 Antitrypsin Deficiency https://ClinicalTrials.gov/show/NCT03008915 Active, not recruiting Columbia University 2018-07-31
NCT02914340 REACH SVS Control Patient Cross-Over Study https://ClinicalTrials.gov/show/NCT02914340 Completed Spiration, Inc. 2017-06-30
NCT02879331 Clinical Study to Evaluate the Exercise Capacity in Patients With Severe Emphysema Treated With Coils https://ClinicalTrials.gov/show/NCT02879331 Recruiting Instituto de Investigación Sanitaria de la Fundación Jiménez Díaz 2021-09-30
NCT02796937 Long Term Safety of Alpha1-Proteinase Inhibitor in Subjects With Alpha1 Antitrypsin Deficiency https://ClinicalTrials.gov/show/NCT02796937 Enrolling by invitation Grifols Therapeutics LLC 2025-12-31
NCT02696564 Losartan Effects on Emphysema Progression https://ClinicalTrials.gov/show/NCT02696564 Active, not recruiting JHSPH Center for Clinical Trials 2021-03-31
NCT02682147 Functional CT Assessment of Pulmonary Arterial Dysfunction in Smoking Associated Emphysema https://ClinicalTrials.gov/show/NCT02682147 Recruiting University of Iowa 2023-02-28
NCT02399514 Improvement of Sleep Quality by RePneu® Coils in Advanced Pulmonary Emphysema https://ClinicalTrials.gov/show/NCT02399514 Completed Institut für Pneumologie Hagen Ambrock eV 2018-03-09
NCT02382367 Prevalence of Alpha-1 Antitrypsin Dysfunction in Pulmonary Emphysema https://ClinicalTrials.gov/show/NCT02382367 Completed Hospices Civils de Lyon 2015-12-31
NCT02107209 Low Cost Biological Lung Volume Reduction Therapy for Advanced Emphysema https://ClinicalTrials.gov/show/NCT02107209 Completed Mansoura University 2015-04-30
NCT01306513 Safety and Feasibility Study of Administration of Mesenchymal Stemcells for Treatment of Emphysema https://ClinicalTrials.gov/show/NCT01306513 Completed Leiden University Medical Center 2012-06-30
NCT02012673 A Safety and Feasibility Study of Re-treating Patients With Severe Emphysema With the RePneu LVRC System. https://ClinicalTrials.gov/show/NCT02012673 Completed University Medical Center Groningen 2016-09-30
NCT02006576 Prostaglandin Inhibition for Emphysema https://ClinicalTrials.gov/show/NCT02006576 Completed University of Nebraska 2018-03-31
NCT01983241 Efficacy and Safety of Alpha1-Proteinase Inhibitor (Human), Modified Process (Alpha-1 MP) in Subjects With Pulmonary Emphysema Due to Alpha1 Antitrypsin Deficiency (AATD) https://ClinicalTrials.gov/show/NCT01983241 Recruiting Grifols Therapeutics LLC 2023-11-30
NCT01872624 Safety Study of Bone-marrow Derived Mesenchymal Stromal Cells Associated With Endobronchial Valves in Emphysema https://ClinicalTrials.gov/show/NCT01872624 Completed Hospital de Clinicas de Porto Alegre 2014-12-31
NCT01869205 The Effect and Mechanism of Bronchoscopic Lung Volume Reduction by Endobronchial Valve in Korean Emphysema Patients https://ClinicalTrials.gov/show/NCT01869205 Completed Asan Medical Center 2014-04-30
NCT01812447 Evaluation of the Spiration® Valve System for Emphysema to Improve Lung Function https://ClinicalTrials.gov/show/NCT01812447 Active, not recruiting Spiration, Inc. 2017-11-30
NCT01796392 Pulmonx Endobronchial Valves Used in Treatment of Emphysema (LIBERATE Study) https://ClinicalTrials.gov/show/NCT01796392 Active, not recruiting Pulmonx Corporation 2017-09-30
NCT02025205 Improving Patient Outcomes by Selective Implantation of the Zephyr EBV - Study https://ClinicalTrials.gov/show/NCT02025205 Completed Pulmonx Corporation 2016-04-30
NCT01744093 Doxycycline for COPD in HIV-Infected Patients https://ClinicalTrials.gov/show/NCT01744093 Active, not recruiting Weill Medical College of Cornell University 2017-10-25
NCT01719263 Sequential Segmental Treatment of Emphysema With Upper Lobe Predominance (STEP-UP) Study https://ClinicalTrials.gov/show/NCT01719263 Completed Uptake Medical Corp 2015-10-31
NCT01710449 Evaluation of Regional Ventilation Using 19F MRI of Inert Perfluorinated Gases Mixed With Oxygen https://ClinicalTrials.gov/show/NCT01710449 Completed Duke University 2012-10-31
NCT01682850 Pulmonary Rehabilitation Before Lung Cancer Resection https://ClinicalTrials.gov/show/NCT01682850 Completed Mayo Clinic 2018-12-31
NCT01615484 Ex-vivo Perfusion and Ventilation of Lungs Recovered From Non-Heart-Beating Donors to Assess Transplant Suitability https://ClinicalTrials.gov/show/NCT01615484 Completed University of North Carolina, Chapel Hill 2016-03-31
NCT01528267 Bronchoscopic Lung Volume Reduction Using Blood https://ClinicalTrials.gov/show/NCT01528267 Completed Chelsea and Westminster NHS Foundation Trust 2013-03-31
NCT01495780 eRT Remote Health Monitoring https://ClinicalTrials.gov/show/NCT01495780 Completed University of California, Los Angeles 2014-08-20
NCT01421082 Evaluation of Physiologic Parameters to Study the Mechanism of Action of the Lung Volume Reduction Coil in Subjects With Homogeneous Emphysema https://ClinicalTrials.gov/show/NCT01421082 Completed PneumRx, Inc. 2013-03-31
NCT01334307 Randomized Comparison of the RePneu Lung Volume Reduction Coil (LVRC) to Standard of Care for the Treatment of Emphysema (RESET Study) https://ClinicalTrials.gov/show/NCT01334307 Completed PneumRx, Inc. 2013-06-30
NCT01328899 Feasibility Study of PneumRx’s Lung Volume Reduction Coil (LVRC) https://ClinicalTrials.gov/show/NCT01328899 Completed PneumRx, Inc. 2013-01-31
NCT03685526 Cinenses Lung Volume Reduction Reverser System First-in-man Study Treating Patients With Severe Emphysema https://ClinicalTrials.gov/show/NCT03685526 Recruiting Lifetech Scientific (Shenzhen) Co., Ltd. 2020-05-31
NCT03673176 Lung Volume Reduction for Severe Emphysema by Stereotactic Ablative Radiation Therapy https://ClinicalTrials.gov/show/NCT03673176 Recruiting Stanford University 2021-12-30
NCT03670121 A Pilot Study to Assess Treatment of Patients With Homogeneous Emphysema Using Sequential Segmental Bronchoscopic Thermal Vapor Ablation (NEXT STEP) https://ClinicalTrials.gov/show/NCT03670121 Active, not recruiting Uptake Medical Technology, Inc. 2020-01-30
NCT03500731 Lung and Bone Marrow Transplantation for Lung and Bone Marrow Failure https://ClinicalTrials.gov/show/NCT03500731 Recruiting University of Pittsburgh 2023-12-31
NCT03474471 A Trial on the Effects of Bronchoscopic Lung Volume Reduction in Severe Emphysema. https://ClinicalTrials.gov/show/NCT03474471 Recruiting University Medical Center Groningen 2021-06-01
NCT01220908 Evaluation of the PneumRx Lung Volume Reduction Coil to Treat Emphysema https://ClinicalTrials.gov/show/NCT01220908 Completed PneumRx, Inc. 2011-03-31
NCT01217671 International Study Evaluating the Safety and Efficacy of Inhaled, Human, Alpha-1 Antitrypsin (AAT) in Alpha-1 Antitrypsin Deficient Patients With Emphysema https://ClinicalTrials.gov/show/NCT01217671 Completed Kamada, Ltd. 2014-11-30
NCT02022683 To Improve Lung Function and Symptoms for Emphysema Patients Using Zephyr Valves https://ClinicalTrials.gov/show/NCT02022683 Completed Pulmonx Corporation 2017-01-20
NCT01213043 Safety and Pharmacokinetics of Alpha-1 Proteinase Inhibitor in Subjects With Alpha1-Antitrypsin Deficiency https://ClinicalTrials.gov/show/NCT01213043 Completed Grifols Therapeutics LLC 2012-01-31
NCT01181466 AeriSeal® System for Lung Volume Reduction in Patients With Advanced Emphysema https://ClinicalTrials.gov/show/NCT01181466 Completed Aeris Therapeutics 2011-05-31
NCT01110252 Safety Study of Cell Therapy to Treat Chronic Obstructive Pulmonary Disease https://ClinicalTrials.gov/show/NCT01110252 Completed UPECLIN HC FM Botucatu Unesp 2010-10-31
NCT01102712 Bronchoscopic Thermal Vapor Ablation (BTVA) for Lung Volume Reduction https://ClinicalTrials.gov/show/NCT01102712 Completed Uptake Medical Corp 2010-12-31
NCT01101958 A Study of the Use of Chartis System to Optimize Subject Selection for Endobronchial Lung Volume Reduction (ELVR) https://ClinicalTrials.gov/show/NCT01101958 Completed Pulmonx Corporation 2013-03-31
NCT01051258 AeriSeal System for Lung Volume Reduction https://ClinicalTrials.gov/show/NCT01051258 Completed Aeris Therapeutics 2011-08-31
NCT01041586 Bronchoscopic Thermal Vapor Ablation (BTVA) for Lung Volume Reduction https://ClinicalTrials.gov/show/NCT01041586 Completed Uptake Medical Corp 2011-01-31
NCT00884962 A Dose Ranging Study of the Aeris Polymeric Lung Volume Reduction (PLVR) System in Patients With Advanced Upper Lobe Predominant Emphysema https://ClinicalTrials.gov/show/NCT00884962 Completed Aeris Therapeutics 2010-05-31
NCT01989182 The Spiration Valve System for the Treatment of Severe Emphysema https://ClinicalTrials.gov/show/NCT01989182 Completed Spiration, Inc. 2016-05-18
NCT00825578 Use of Endobronchial Valves in Non-Upper Lobe Heterogeneous Emphysema https://ClinicalTrials.gov/show/NCT00825578 Completed Royal Brompton & Harefield NHS Foundation Trust 2010-12-31
NCT03205826 Chartis Collateral Ventilation Measurement: Conscious Sedation Versus General Anesthesia https://ClinicalTrials.gov/show/NCT03205826 Completed University Medical Center Groningen 2019-01-22
NCT03733470 Hypoxic Pulmonary Vasoconstriction Pilot Study https://ClinicalTrials.gov/show/NCT03733470 Completed University of Iowa 2014-01-13
NCT01953523 Safety and Clinical Outcomes Study: SVF Deployment for Orthopedic, Neurologic, Urologic, and Cardio-pulmonary Conditions https://ClinicalTrials.gov/show/NCT01953523 Completed Cell Surgical Network Inc. 2016-12-31
NCT01860898 A Phase I Study of iPS Cell Generation From Patients With COPD https://ClinicalTrials.gov/show/NCT01860898 Active, not recruiting Mayo Clinic 2021-01-31
NCT00720226 Efficacy of Losartan in Preventing Progression of COPD https://ClinicalTrials.gov/show/NCT00720226 Completed Johns Hopkins University 2014-08-31
NCT00684892 Safety and Feasibility Study of the Chartis System With Heterogeneous Emphysema Prior to Endobronchial Lung Volume Reduction (ELVR) https://ClinicalTrials.gov/show/NCT00684892 Completed Pulmonx Corporation 2008-11-30
NCT00683722 PROCHYMALâ„¢ (Human Adult Stem Cells) for the Treatment of Moderate to Severe Chronic Obstructive Pulmonary Disease (COPD) https://ClinicalTrials.gov/show/NCT00683722 Completed Mesoblast, Ltd. 2009-03-09
NCT00680056 Add-on Effects of Tiotropium Over Formoterol in Exercise Tolerance on Chronic Obstructive Pulmonary Disease Patients https://ClinicalTrials.gov/show/NCT00680056 Completed Federal University of São Paulo 2008-12-31
NCT00670007 Extension Study of Zemaira® i.v. Administration in Subjects With Emphysema Due to alpha1-proteinase Inhibitor Deficiency. https://ClinicalTrials.gov/show/NCT00670007 Completed CSL Behring 2014-09-30
NCT00630227 Biologic Lung Volume Reduction (BLVR) Phase 2 Homogeneous Study https://ClinicalTrials.gov/show/NCT00630227 Completed Aeris Therapeutics 2009-12-31
NCT00566839 Randomized Comparison of Awake Nonresectional Versus Nonawake Resectional Lung Volume Reduction Surgery https://ClinicalTrials.gov/show/NCT00566839 Completed University of Rome Tor Vergata NA
NCT00517998 Israeli Biologic Lung Volume Reduction (BLVR) Phase 1 Emphysema Study https://ClinicalTrials.gov/show/NCT00517998 Completed Aeris Therapeutics 2009-03-31
NCT00515164 US Biologic Lung Volume Reduction (BLVR) Phase 2 Emphysema Study https://ClinicalTrials.gov/show/NCT00515164 Completed Aeris Therapeutics 2008-04-30
NCT00475007 Clinical Trial to Evaluate the Safety and Effectiveness of the IBV® Valve System for the Treatment of Severe Emphysema https://ClinicalTrials.gov/show/NCT00475007 Completed Spiration, Inc. 2011-02-28
NCT00424528 Efficacy Safety Study of Arformoterol/Tiotropium Combination Versus Either Therapy Alone in Chronic Obstructive Pulmonary Disease (COPD) https://ClinicalTrials.gov/show/NCT00424528 Completed Sunovion 2007-10-31
NCT00413205 TESRA: (Treatment of Emphysema With a Gamma-Selective Retinoid Agonist) https://ClinicalTrials.gov/show/NCT00413205 Completed Hoffmann-La Roche 2010-05-31
NCT00347659 US 10 mL Biologic Lung Volume Reduction (BLVR) Phase 1 Emphysema Study https://ClinicalTrials.gov/show/NCT00347659 Completed Aeris Therapeutics 2006-12-31
NCT00269087 GW815SF For Chronic Obstructive Pulmonary Disease (Chronic Bronchitis, Emphysema) https://ClinicalTrials.gov/show/NCT00269087 Completed GlaxoSmithKline 2006-10-01
NCT00263887 Alpha-1-Antitrypsin (AAT) To Treat Emphysema In AAT-Deficient Patients (EXACTLE) https://ClinicalTrials.gov/show/NCT00263887 Completed Grifols Therapeutics LLC 2007-01-31
NCT00261833 Zemaira in Subjects With Emphysema Due to Alpha1-Proteinase Inhibitor Deficiency https://ClinicalTrials.gov/show/NCT00261833 Completed CSL Behring 2012-09-30
NCT00250679 Safety and Efficacy of Arformoterol Tartrate Inhalation Solution in Subjects With Chronic Obstructive Pulmonary Disease https://ClinicalTrials.gov/show/NCT00250679 Completed Sunovion 2007-10-31
NCT00207337 Exhale (R) Stent for Emphysema https://ClinicalTrials.gov/show/NCT00207337 Completed Broncus Technologies 2006-05-31
NCT00129584 Endobronchial Valve for Emphysema Palliation Trial (VENT) https://ClinicalTrials.gov/show/NCT00129584 Completed Emphasys Medical NA
NCT00123422 Innovation in Pulmonary Rehabilitation https://ClinicalTrials.gov/show/NCT00123422 Completed VA Office of Research and Development 2009-08-31
NCT00104637 Sildenafil for Chronic Obstructive Pulmonary Disease https://ClinicalTrials.gov/show/NCT00104637 Completed Kawut, Steven, MD 2008-11-30
NCT00085852 US 10 mL Bronchoscopic Lung Volume Reduction (BLVR) Phase 1 Emphysema Study - Initial Formulation https://ClinicalTrials.gov/show/NCT00085852 Completed Aeris Therapeutics 2006-10-31
NCT00051792 Yoga for Treating Shortness of Breath in Chronic Obstructive Pulmonary Disease (COPD) https://ClinicalTrials.gov/show/NCT00051792 Completed National Center for Complementary and Integrative Health (NCCIH) NA
NCT00034112 Efficacy of Osteopathic Manipulation in Chronic Obstructive Pulmonary Disease https://ClinicalTrials.gov/show/NCT00034112 Completed National Center for Complementary and Integrative Health (NCCIH) NA
NCT00018525 Lung Volume Reductions Surgery (LVRS) Study https://ClinicalTrials.gov/show/NCT00018525 Completed VA Office of Research and Development NA
NCT00435253 US 10 mL Biologic Lung Volume Reduction (BLVR) Phase 2 Emphysema Study https://ClinicalTrials.gov/show/NCT00435253 Completed Aeris Therapeutics 2009-06-30
NCT00000606 National Emphysema Treatment Trial (NETT) https://ClinicalTrials.gov/show/NCT00000606 Completed National Heart, Lung, and Blood Institute (NHLBI) 2005-12-31
NCT00000573 Emphysema: Physiologic Effects of Nutritional Support https://ClinicalTrials.gov/show/NCT00000573 Completed National Heart, Lung, and Blood Institute (NHLBI) NA
NCT00000621 Feasibility of Retinoic Acid Treatment in Emphysema (FORTE) https://ClinicalTrials.gov/show/NCT00000621 Completed National Heart, Lung, and Blood Institute (NHLBI) 2004-12-31

Observational Studiess

#If less then 500 studies

nct_id brief_title link overall_status source primary_completion_date
NCT03010566 Lung Volume Reduction Coil Microbiome Study https://ClinicalTrials.gov/show/NCT03010566 Recruiting Royal Brompton & Harefield NHS Foundation Trust 2020-01-31
NCT02719184 Longitudinal Follow up to Assess Biomarkers Predictive of Emphysema Progression in Patients With COPD (Chronic Obstructive Pulmonary Disease) https://ClinicalTrials.gov/show/NCT02719184 Active, not recruiting Boehringer Ingelheim 2021-03-29
NCT02611947 CT Indexes of Emphysema and Airways in Healthy Volunteers: Normal Values; Relations With Gender, Height and Weight https://ClinicalTrials.gov/show/NCT02611947 Completed Erasme University Hospital 2011-06-30
NCT02056158 HIV+ Alveolar Macrophage Oxidant-mediated Apoptosis of Pulmonary Endothelium https://ClinicalTrials.gov/show/NCT02056158 Recruiting Weill Medical College of Cornell University 2021-08-31
NCT01515709 Is the Short Physical Performance Battery a Useful Outcome Measure in Chronic Obstructive Pulmonary Disease https://ClinicalTrials.gov/show/NCT01515709 Completed Royal Brompton & Harefield NHS Foundation Trust 2013-09-30
NCT01507415 Do the SPPB and 4-metre Gait Speed Predict Hospital Readmission in Patients Hospitalised for Acute Exacerbation if COPD? https://ClinicalTrials.gov/show/NCT01507415 Completed Royal Brompton & Harefield NHS Foundation Trust 2013-02-28
NCT01393379 ELVR in PH Patients With Severe Emphysema https://ClinicalTrials.gov/show/NCT01393379 Completed Heidelberg University 2014-05-31
NCT01326572 Lung HIV Disease in a Large Cohort-Pitt https://ClinicalTrials.gov/show/NCT01326572 Completed University of Pittsburgh 2016-01-31
NCT02810327 Alpha-1 Carrier Genomics Study https://ClinicalTrials.gov/show/NCT02810327 Completed Medical University of South Carolina 2017-04-30
NCT04012359 Description of Bullous Emphysema Using Lung Ultrasound and Comparison to the Characteristics of Pneumothorax https://ClinicalTrials.gov/show/NCT04012359 Recruiting University Hospital, Rouen 2021-07-31
NCT01229020 Distribution of Regional Lung Function by Vibration Response Imaging https://ClinicalTrials.gov/show/NCT01229020 Completed Deep Breeze 2006-01-31
NCT01192932 Effects of Nycthemeral Variations on Computed Tomography (CT) Parameters Reflecting Airways Remodelling, and Pulmonary Emphysema Extent in Chronic Obstructive Pulmonary Disease (COPD) https://ClinicalTrials.gov/show/NCT01192932 Completed Erasme University Hospital 2011-06-30
NCT01142531 Effects of Bronchodilation on Computed Tomography (CT) Parameters Reflecting Airways Remodelling, and Pulmonary Emphysema Extent. https://ClinicalTrials.gov/show/NCT01142531 Completed Erasme University Hospital 2011-06-30
NCT01121367 Study on Phenotypic Characterization of Combined Pulmonary Fibrosis and Emphysema https://ClinicalTrials.gov/show/NCT01121367 Completed Beijing Chao Yang Hospital 2011-06-30
NCT00974064 The Natural History of Gene Expression in the Lung Cells of Non-Smokers, Smokers and Ex-Smokers in Health and Disease https://ClinicalTrials.gov/show/NCT00974064 Active, not recruiting Weill Medical College of Cornell University 2020-03-31
NCT00869544 Pneumocystis in Pathogenesis of HIV-associated Emphysema https://ClinicalTrials.gov/show/NCT00869544 Completed University of Pittsburgh 2010-09-30
NCT02827721 Evaluation of Novel Lung Function Parameters in Patients With Chronic Obstructive Pulmonary Disease (COPD) https://ClinicalTrials.gov/show/NCT02827721 Recruiting Universitätsmedizin Mannheim 2020-11-30
NCT00757120 Biomarkers and Genetic Factors Related to Emphysema https://ClinicalTrials.gov/show/NCT00757120 Completed Washington University School of Medicine 2011-09-30
NCT00675454 Evaluating the Effects of Surgical and Non-Surgical Treatment Options in People With Emphysema https://ClinicalTrials.gov/show/NCT00675454 Enrolling by invitation Washington University School of Medicine 2020-12-31
NCT01305668 Rehabilitation in Chronic Obstructive Pulmonary Disease (COPD) Patients With Emphysema https://ClinicalTrials.gov/show/NCT01305668 Completed Villa Pineta Hospital 2012-12-31
NCT00608764 Examining the Genetic Factors That May Cause Chronic Obstructive Pulmonary Disease (COPD) https://ClinicalTrials.gov/show/NCT00608764 Active, not recruiting Brigham and Women’s Hospital 2022-12-31
NCT00570544 Tiotropium Induced Bronchodilation in Lung CT Scored Emphysema https://ClinicalTrials.gov/show/NCT00570544 Completed Gelb, Arthur F., M.D. NA
NCT00528944 Single-Breath Measurement Underestimates Ventilatory Volume According to Emphysema Severity https://ClinicalTrials.gov/show/NCT00528944 Completed Columbia University 2008-07-31
NCT00001462 Characterization of the Pathobiology of Early Lung Destruction in Alpha 1-Antitrypsin Deficient Individuals https://ClinicalTrials.gov/show/NCT00001462 Completed National Institutes of Health Clinical Center (CC) NA

Registries

#If less then 500 registries

nct_id brief_title link overall_status source primary_completion_date
NCT04161235 Post-Market Clinical Evaluation of the Zephyr Valve 5.5-LP EBV https://ClinicalTrials.gov/show/NCT04161235 Enrolling by invitation Pulmonx Corporation 2021-04-30
NCT03755505 The Microbiome of Sputum, Urine and Feces in Healthy Persons and Chronic Obstructive Pulmonary Disease (COPD) Patients https://ClinicalTrials.gov/show/NCT03755505 Recruiting Asan Medical Center 2019-03-31
NCT03318406 Post-Market BTVA Registry https://ClinicalTrials.gov/show/NCT03318406 Recruiting Uptake Medical Technology, Inc. 2024-12-01
NCT03263130 Site and Mechanism(s) of Expiratory Airflow Limitation in COPD, Emphysema and Asthma-COPD Overlap https://ClinicalTrials.gov/show/NCT03263130 Recruiting Gelb, Arthur F., M.D. 2022-01-01
NCT02803242 COPD Patient-Powered Research Network https://ClinicalTrials.gov/show/NCT02803242 Recruiting COPD Foundation 2025-01-31
NCT04186546 Zephyr Valve Registry (ZEVR) https://ClinicalTrials.gov/show/NCT04186546 Enrolling by invitation Pulmonx Corporation 2021-12-31
NCT00307281 Emphysema/COPD Research Registry https://ClinicalTrials.gov/show/NCT00307281 Recruiting University of Pittsburgh 2030-07-31